jueves, 2 de febrero de 2012

OTIFLOX otitis

Ofloxacin 0.3% w/v
Clotrimazole IP 1% w/v
Beclomethasone Dipropionate IP 0.025 % w/v
Lignocaine Hydrochloride IP 2% w/v
Propylene Glycol IP & Glycerine IP [Base]
Glacial Acetic Acid IP, Polyoxyethylene
Castor Oil derivatives IHS, Purified Water
Otiflox Ear Drops provides an antibacterial and antifungal along with an antiinflammatory agent. It may be used to prevent or treat ear infections. Otiflox Ear
Drops has been specially formulated to maintain the natural environment of the
external ear canal.
Ofloxacin is a fluoroquinolone that has a broad spectrum of activity against otic
pathogens but lacks the capacity for ototoxicity. Hence ofloxacin is preferred to
aminoglycosides for any application within the middle ear space.
Ofloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial
enzyme that is essential in DNA replication, repair, deactivation and transcription.
Ofloxacin has been shown to be active against the following organisms responsible
clinically for otic infections:
Staphylococcus aureus
Streptococcus pneumoniae
Escherichia coli
Haemophilus influenzae
Moraxella catarrhalis
Proteus mirabilis
Pseudomonas aeruginosa
Clotrimazole is a synthetic imidazole derivative. Clotrimazole is a broad-spectrum
antifungal agent that has fungicidal activity against fungi responsible for superficial
mycotic infections affecting the outer or middle ear including Candida,
Microsporum, Trichophyton.
Clotrimazole inhibits fungal cytochrome P-450 synthesis of ergosterol, which
decreases fungal cell wall integrity. By inhibit

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